Editorial: Vibrionaceae Diversity, Multidrug Resistance and Management

Editorial: Vibrionaceae Diversity, Multidrug Resistance and Management

Multidrug Resistance in Infants and Children

Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...

Multidrug resistance associated proteins in multidrug resistance

Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins named ATP-binding cassette (ABC) transporters. These ABC transporters together form the largest branch of proteins within the human body. The MRP family comprises of 13 members, of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer dru...

SXT/R391 integrative and conjugative elements in Proteus species reveal abundant genetic diversity and multidrug resistance

SXT/R391 integrative and conjugative elements (ICEs) are self-transmissible mobile genetic elements that are found in most members of Enterobacteriaceae. Here, we determined fifteen SXT/R391 ICEs carried by Proteus isolates from food (4.2%) and diarrhoea patients (17.3%). BLASTn searches against GenBank showed that the fifteen SXT/R391 ICEs were closely related to that from different Enterobact...

Editorial: Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues

Tumor drug resistance is the leading cause of chemotherapy treatment failure. One of the more relevant mechanisms is represented by multidrug resistance (MDR) that leads to a reduced cellular accumulation of drugs due to increased efflux out of cells by the overexpression of several ATPdependent efflux pumps or transporters. These proteins belong to the ATP-binding cassette (ABC) family and the...